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Pitx-1 is a member of the family of bicoid-related vertebrate homeobox genes; it was originally identified as a tissue-specific transcriptional regulator of the proopiomelacortin gene. Here we report on the embryonic expression of Xpitx-1, which is expressed in the anterior neural ridge and in the cement gland Anlage during late gastrulation/early neurulation. In tadpole stage embryos Xpitx-1 transcripts are primarily detected in the cement gland, stomodeal-hypophyseal Anlage, oral epithelia and lens placode. Therefore, Xpitx-1 may be part of the genetic network that controls the early development of these structures.
Fig. 2. Expression of Xpitx-1 in during Xenopus development. Whole-mount in situ hybridization was performed using Xpitx-1 antisense RNA and staged Xenopus embryos. Nieuwkoop±Faber stages of embryogenesis are indicated. (A,B,D,E,G) Anterior view; (C,F,H) horizontal sections as indicated by the red dashed line across the embryos in (B,E,G), respectively. (I,L) are lateral views, only the anterior halves of the embryos are shown. To improve resolution, a cleared embryo is shown in (L). (J) Frontal section and (K) parasagittal section of the embryo shown in (I); (M) frontal section of the embryo shown in (L). Details of (C,H,M) are shown in (C',H',M'), respectively, as indicated by the lines. Abbreviations: ar, archenteron; bv, brain ventricle; cga, cement gland Anlage; ele, epithelial layer of neuroectoderm; endo, endodermal layer; ev, eye vesicle; eym, endodermal yolk mass; lp, lens placode; lv, lens vesicle; ple, presumptive lens ectoderm; pt, pituitary; sle, sensorial layer of neuroectoderm; st, stomodeum; oe, oral epithelia.