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XB-ART-1250
Dev Dyn November 1, 2005; 234 (3): 802-7.
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Expression of synaptic vesicle two-related protein SVOP in the developing nervous system of Xenopus laevis.

Logan MA , Steele MR , Vetter ML .


Abstract
Synaptic vesicle-associated proteins are important regulators of neurotransmitter release at synaptic terminals in mature animals. Some synaptic vesicle-associated proteins are also expressed during development, although their contribution to development is not as clear. Here, we describe the cloning and developmental expression pattern of the Xenopus laevis synaptic vesicle-associated protein SVOP, a gene first identified as an immediate target for proneural basic helix-loop-helix factors. Alignment analysis revealed a high level of identity between the SVOP protein sequences from Xenopus and other vertebrates. In developing Xenopus embryos, SVOP expression is restricted to the nervous system and is first detectable at the mid-neurula stage. As development progresses SVOP becomes broadly expressed throughout the central nervous system. Our observation that SVOP is expressed in the developing Xenopus nervous system suggests that it may be involved in neuron formation, maturation, or neuronal function.

PubMed ID: 16217738
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: neurod1 runx1 svop tlx1 tlx3


Article Images: [+] show captions