XB-ART-12925
Biochemistry
1999 Jun 01;3822:7008-18. doi: 10.1021/bi990224y.
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The methyl-CpG binding transcriptional repressor MeCP2 stably associates with nucleosomal DNA.
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We have investigated the interactions of the methyl-CpG binding transcriptional repressor MeCP2 with nucleosomal DNA. We find that MeCP2 forms discrete complexes with nucleosomal DNA associating with methyl-CpGs exposed in the major groove via the methyl-CpG-binding domain (MBD). In addition to the MBD, the carboxyl-terminal segment of MeCP2 facilitates binding both to naked DNA and to the nucleosome core. These observations provide a molecular mechanism by which MeCP2 can gain access to chromatin in order to target corepressor complexes that further modify chromatin structure.
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Species referenced: Xenopus laevis
Genes referenced: mecp2