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Antimicrob Agents Chemother
1999 May 01;435:1091-7. doi: 10.1128/AAC.43.5.1091.
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In vivo and in vitro toxicodynamic analyses of new quinolone-and nonsteroidal anti-inflammatory drug-induced effects on the central nervous system.
Kita H
,
Matsuo H
,
Takanaga H
,
Kawakami J
,
Yamamoto K
,
Iga T
,
Naito M
,
Tsuruo T
,
Asanuma A
,
Yanagisawa K
,
Sawada Y
.
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We investigated the correlation between an in vivo isobologram based on the concentrations of new quinolones (NQs) in braintissue and the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) for the occurrence of convulsions in mice and an in vitro isobologram based on the concentrations of both drugs for changes in the gamma-aminobutyric acid (GABA)-induced current response in Xenopus oocytes injected with mRNA from mouse brains in the presence of NQs and/or NSAIDs. After the administration of enoxacin (ENX) in the presence or absence of felbinac (FLB), ketoprofen (KTP), or flurbiprofen (FRP), a synergistic effect was observed in the isobologram based on the threshold concentration in braintissue between mice with convulsions and those without convulsions. The three NSAIDs did not affect the pharmacokinetic behavior of ENX in the brain. However, the ENX-induced inhibition of the GABA response in the GABAA receptor expressed in Xenopus oocytes was enhanced in the presence of the three NSAIDs. The inhibition ratio profiles of the GABA responses for both drugs were analyzed with a newly developed toxicodynamic model. The inhibitory profiles for ENX in the presence of NSAIDs followed the order KTP (1.2 microM) > FRP (0. 3 microM) > FLB (0.2 microM). These were 50- to 280-fold smaller than those observed in the absence of NSAIDs. The inhibition ratio (0.01 to 0.02) of the GABAA receptor in the presence of both drugs was well-fitted to the isobologram based on threshold concentrations of both drugs in braintissue between mice with convulsions and those without convulsions, despite the presence of NSAIDs. In mice with convulsions, the inhibitory profiles of the threshold concentrations of both drugs in braintissue of mice with convulsions and those without convulsions can be predicted quantitatively by using in vitro GABA response data and toxicodynamic model.
Anastasio,
Norfloxacin and seizures.
1988,
Pubmed
Asanuma,
The distribution of GABA and glycine response in the mouse brain using Xenopus oocytes.
1987,
Pubmed
,
Xenbase
Barnett,
Pharmacokinetic determination of relative potency of quinolone inhibition of caffeine disposition.
1990,
Pubmed
Chomczynski,
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
1987,
Pubmed
Gessner,
A study of the interaction of the hypnotic effects and of the toxic effects of chloral hydrate and ethanol.
1970,
Pubmed
Horikoshi,
Taurine and beta-alanine act on both GABA and glycine receptors in Xenopus oocyte injected with mouse brain messenger RNA.
1988,
Pubmed
,
Xenbase
Katagiri,
Simultaneous determination of ofloxacin, fenbufen and felbinac in rat plasma by high-performance liquid chromatography.
1988,
Pubmed
Katagiri,
High-performance liquid chromatographic procedure for the simultaneous determination of norfloxacin, fenbufen and felbinac in rat plasma.
1989,
Pubmed
Kawakami,
Inhibition of GABAA receptor-mediated current responses by enoxacin (new quinolone) and felbinac (non-steroidal anti-inflammatory drug) in Xenopus oocytes injected with mouse-brain messenger RNA.
1993,
Pubmed
,
Xenbase
Kawakami,
Inhibitory effect of new quinolones on GABA(A) receptor-mediated response and its potentiation with felbinac in Xenopus oocytes injected with mouse-brain mRNA: correlation with convulsive potency in vivo.
1997,
Pubmed
,
Xenbase
LOEWE,
The problem of synergism and antagonism of combined drugs.
1953,
Pubmed
Maesen,
Quinolones and raised plasma concentrations of theophylline.
1984,
Pubmed
Miyama,
P-glycoprotein-mediated transport of itraconazole across the blood-brain barrier.
1998,
Pubmed
Nakamura,
Determination of a new antibacterial agent (AT-2266) and its metabolites in plasma and urine by high-performance liquid chromatography.
1983,
Pubmed
Paton,
Clinical features and management of adverse effects of quinolone antibacterials.
1991,
Pubmed
Polk,
Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers.
1989,
Pubmed
Sano,
Inhibitory effect of enoxacin, ofloxacin and norfloxacin on renal excretion of theophylline in humans.
1989,
Pubmed
Schwartz,
Potential neurologic toxicity related to ciprofloxacin.
1990,
Pubmed
Staib,
Interaction between quinolones and caffeine.
1987,
Pubmed
Stille,
Decrease of caffeine elimination in man during co-administration of 4-quinolones.
1987,
Pubmed
Takedomi,
Quantitative prediction of the interaction of midazolam and histamine H2 receptor antagonists in rats.
1998,
Pubmed
Tallarida,
Statistical analysis of drug-drug and site-site interactions with isobolograms.
1989,
Pubmed
Tallarida,
Further characterization of a control model for ligand-receptor interaction: phase plane geometry, stability, and oscillation.
1990,
Pubmed
Tallarida,
Statistical analysis of drug combinations for synergism.
1992,
Pubmed
Tatsuta,
Functional involvement of P-glycoprotein in blood-brain barrier.
1992,
Pubmed
Tsuji,
Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes.
1988,
Pubmed
Tsuji,
Effect of the anti-inflammatory agent fenbufen on the quinolone-induced inhibition of gamma-aminobutyric acid binding to rat brain membranes in vitro.
1988,
Pubmed
Wijnands,
Enoxacin raises plasma theophylline concentrations.
1984,
Pubmed
Wijnands,
The influence of quinolone derivatives on theophylline clearance.
1986,
Pubmed
Yamaoka,
A pharmacokinetic analysis program (multi) for microcomputer.
1981,
Pubmed
