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XB-ART-13135
Microsc Res Tech 1999 Mar 15;446:435-45. doi: 10.1002/(SICI)1097-0029(19990315)44:6<435::AID-JEMT5>3.0.CO;2-T.
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Microtubule dynamics in Xenopus egg extracts.

Shirasu M , Yonetani A , Walczak CE .


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The organization and function of microtubules change dramatically during the cell cycle. At the onset of mitosis, a radial array of microtubules is broken down and reorganized into a bipolar spindle. This event requires changes in the dynamic behavior of individual microtubules. Through the use of Xenopus laevis egg extracts, a number of proteins affecting microtubule behavior have been identified. Recently, progress has also been made towards understanding how the activities of such microtubule-affecting proteins are regulated in a cell cycle-dependent manner. It is hoped that understanding how microtubule behavior is controlled during the cell cycle in vitro may illuminate the role of microtubule dynamics in various cellular processes.

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