Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-13529
Biol Pharm Bull January 1, 1999; 22 (1): 73-6.
Show Gene links Show Anatomy links

Biological activities of 1,1,6-trisubstituted indanes: beyond magainin 2.

Numao N , Hirota Y , Iwahori A , Kidokoro S , Sasatsu M , Kondo I , Itoh S , Itoh E , Katoh T , Shimozono N , Yamazaki A , Takao K , Kobayashi S .


Abstract
MSI-78 is a peptide analog of naturally occurring magainin 2 isolated from the skin of Xenopus laevis. The peptide is known to have one of the strongest antibacterial activities in magainin 2 analogs against methicillin-resistant Staphylococcus aureus (MRSA). To find novel compounds superior to MSI-78, we have further designed, synthesizing 1,1-di(4-aminobutyl)-6-benzylindane (PM4) and 1,1-dibenzyl-6-(4-aminobutyl) indane (PM5), and tested their inhibitory ability of the growth of S. aureus. In an in vitro assay, PM4 showed the same antibacterial activity against the bacterium as MSI-78, and non-hemolytic activity against human red blood cells (RBCs) at the MIC (minimum inhibitory concentration) value, in contrast to the latter. On the other hand, PM5 showed stronger antibacterial activity than MSI-78, but being still accompanied with hemolysis at the MIC value. Otherwise, stronger decarboxylase activity for oxaloacetate was observed in PM5, rather than magainin 2 analogs or Oxaldie 1 as a control peptide, but not in PM4.

PubMed ID: 9989665
Article link: Biol Pharm Bull


Species referenced: Xenopus laevis
Genes referenced: magainins