C R Acad Sci III 1998 May 01;3215:355-64. doi: 10.1016/s0764-4469(98)80298-9.

Localization of Myf-5, MRF4 and alpha cardiac actin mRNAs in regenerating Xenopus skeletal muscle.

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We have analysed the spatial and temporal expression patterns of Myf-5, MRF4 and alpha cardiac actin mRNAs during muscle regeneration following cardiotoxin injury in adult Xenopus laevis using in situ hybridization. Myf-5 transcripts began to be detected in the activated satellite cells as early as the beginning of the regeneration process, then dramatically decreased in young plurinucleated myotubes. MRF4 mRNA was detected later, just before the young myotube stage, and was strongly expressed during the different stages of the maturation of myotubes. Like Myf-5, alpha cardiac actin mRNA began to accumulate early in activated satellite cells. These results, which contribute to an overview of the expression of the genes coding for myogenic bHLH proteins during muscle regeneration, are discussed in relation to the expression of these factors during development.

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Species referenced: Xenopus laevis
Genes referenced: actc1 actl6a myf5 myf6