Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-14466
Dev Biol 1998 Jul 15;1992:216-25. doi: 10.1006/dbio.1998.8889.
Show Gene links Show Anatomy links

Mammalian BarH homologue is a potential regulator of neural bHLH genes.

Saito T , Sawamoto K , Okano H , Anderson DJ , Mikoshiba K .


???displayArticle.abstract???
Vertebrate neurogenesis involves sequential actions of transcription factors. neurogenins, encoding Atonal-related bHLH transcription factors, function as neuronal determination genes in Xenopus. neurogenins and antother bHLH factor gene, Mash1, are expressed in distinct subsets or areas of cells giving rise to neurons, suggesting that these genes play important roles to generate distinct populations of neurons. A mammalian homologue of BarH (MBH1) is expressed in a complementary pattern to Mash1 expression in the developing nervous system like neurogenins. Forced expression of MBH1 down-regulates expression of Mash1 and up-regulates neurogenin2/Math4A, a member of neurogenins, in P19 cells during neuronal differentiation. This suggests that MBH1 is a potential regulator of mammalian neural bHLH genes, thereby establishing distinct pathways of neuronal differentiation.

???displayArticle.pubmedLink??? 9698441
???displayArticle.link??? Dev Biol


Species referenced: Xenopus
Genes referenced: ascl1 neurog2