Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
1998 May 26;9511:6198-203. doi: 10.1073/pnas.95.11.6198.
Show Gene links
Show Anatomy links
Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis.
Shawlot W
,
Deng JM
,
Behringer RR
.
???displayArticle.abstract???
The Xenopus cerberus gene encodes a secreted factor that is expressed in the anterior endomesoderm of gastrula stage embryos and can induce the formation of ectopic heads when its mRNA is injected into Xenopus embryos [Bouwmeester, T., Kim, S., Lu, B. & De Robertis, E. M. (1996) Nature (London) 382, 595-601]. Here we describe the existence of a cerberus-related gene, Cerr1, in the mouse. Cerr1 encodes a putative secreted protein that is 48% identical to cerberus over a 110-amino acid region. Analysis of a mouse interspecific backcross panel demonstrated that Cerr1 mapped to the central portion of mouse chromosome 4. In early gastrula stage mouse embryos, Cerr1 is expressed in the anterior visceral endoderm and in the anterior definitive endoderm. In somite stage embryos, Cerr1 expression is restricted to the most recently formed somites and in the anterior presomitic mesoderm. Germ layer explant recombination assays demonstrated that Cerr1-expressing somitic-presomitic mesoderm, but not older Cerr1-nonexpressing somitic mesoderm, was able to mimic the anterior neuralizing ability of anteriormesendoderm and maintain Otx2 expression in competent ectoderm. In most Lim1-/- headless embryos, Cerr1 expression in the anterior endoderm was weak or absent. These results suggest that Cerr1 may play a role in anterior neural induction and somite formation during mouse development.
Acampora,
Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.
1995, Pubmed
Acampora,
Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.
1995,
Pubmed
Albano,
Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain.
1994,
Pubmed
Altschul,
Basic local alignment search tool.
1990,
Pubmed
Ang,
Anterior mesendoderm induces mouse Engrailed genes in explant cultures.
1993,
Pubmed
Ang,
Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants.
1994,
Pubmed
Ang,
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.
1996,
Pubmed
Barnes,
Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis.
1994,
Pubmed
,
Xenbase
Beddington,
An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo.
1989,
Pubmed
Bouwmeester,
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer.
1996,
Pubmed
,
Xenbase
Conlon,
Notch1 is required for the coordinate segmentation of somites.
1995,
Pubmed
Del Amo,
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development.
1992,
Pubmed
,
Xenbase
EYAL-GILADI,
Dynamic aspects of neural induction in amphibia.
1954,
Pubmed
Filosa,
Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis.
1997,
Pubmed
Greenwald,
The lin-12 locus specifies cell fates in Caenorhabditis elegans.
1983,
Pubmed
Hemmati-Brivanlou,
Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity.
1994,
Pubmed
,
Xenbase
Hemmati-Brivanlou,
Region-specific neural induction of an engrailed protein by anterior notochord in Xenopus.
1990,
Pubmed
,
Xenbase
Hermesz,
Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo.
1996,
Pubmed
Kozak,
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.
1987,
Pubmed
Lawson,
Clonal analysis of epiblast fate during germ layer formation in the mouse embryo.
1991,
Pubmed
Li,
Esx1, a novel X chromosome-linked homeobox gene expressed in mouse extraembryonic tissues and male germ cells.
1997,
Pubmed
Lints,
Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
1993,
Pubmed
Mangold,
[Not Available].
1927,
Pubmed
Matsuo,
Mouse Otx2 functions in the formation and patterning of rostral head.
1995,
Pubmed
Olopade,
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.
1992,
Pubmed
Parameswaran,
Regionalisation of cell fate and morphogenetic movement of the mesoderm during mouse gastrulation.
1995,
Pubmed
Piccolo,
Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.
1996,
Pubmed
,
Xenbase
Reaume,
Expression analysis of a Notch homologue in the mouse embryo.
1992,
Pubmed
,
Xenbase
Rowe,
Maps from two interspecific backcross DNA panels available as a community genetic mapping resource.
1994,
Pubmed
Sasai,
Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes.
1994,
Pubmed
,
Xenbase
Sasaki,
Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.
1993,
Pubmed
Shawlot,
Requirement for Lim1 in head-organizer function.
1995,
Pubmed
Smith,
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos.
1992,
Pubmed
,
Xenbase
Swiatek,
Notch1 is essential for postimplantation development in mice.
1994,
Pubmed
Thomas,
Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo.
1996,
Pubmed
Varlet,
nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation.
1997,
Pubmed
Zimmerman,
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.
1996,
Pubmed
,
Xenbase
