XB-ART-15119
Curr Opin Cell Biol
1998 Apr 01;102:188-94. doi: 10.1016/s0955-0674(98)80141-5.
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Mads and Smads in TGF beta signalling.
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The discovery of the Mothers against dpp (Mad) gene in Drosophila has opened a window on an entirely unique signalling pathway that functions to mediate responses to the tumour growth factor beta (TGF beta) superfamily. This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases.
???displayArticle.pubmedLink??? 9561843
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Species referenced: Xenopus
Genes referenced: dspp tgfb1
GO keywords: regulation of transforming growth factor beta receptor signaling pathway
???displayArticle.disOnts??? cancer