XB-ART-15519Nature January 22, 1998; 391 (6665): 357-62.
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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann''s organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 s a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.
PubMed ID: 9450748
Article link: Nature
Species referenced: Xenopus
Genes referenced: dkk1