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Cell October 4, 1996; 87 (1): 43-52.
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Identification of neurogenin, a vertebrate neuronal determination gene.

Ma Q , Kintner C , Anderson DJ .

Several bHLH proteins are involved in vertebrate neurogenesis, but those controlling early stages of neuronal determination have not yet been identified. Here we describe a novel, NeuroD-related bHLH protein, NEUROGENIN, whose expression precedes that of NeuroD in both mouse and Xenopus. Expression of Xenopus NEUROGENIN-related-1 (X-NGNR-1) defines the three prospective territories of primary neurogenesis. Overexpression of X-NGNR-1 (or NEUROGENIN) induces ectopic neurogenesis and ectopic expression of XNeuroD mRNA. Endogenous X-ngnr-1 expression becomes restricted to subsets of cells by lateral inhibition, mediated by X-Delta-1 and X-Notch. The properties of X-NGNR-1 are thus analogous to those of the Drosophila proneural genes, suggesting that it functions as a vertebrate neuronal determination factor.

PubMed ID: 8858147
Article link: Cell

Species referenced: Xenopus
Genes referenced: actl6a ascl1 atoh1 dll1 ncam1 neurod1 neurod6 neurog1 neurog2 nog notch1 npat rbpj tbx2 tbxt tubb2b

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