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Proc Natl Acad Sci U S A July 3, 1995; 92 (14): 6474-8.
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A type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus.

Mahony D , Gurdon JB .

We have cloned a type I serine/threonine kinase receptor, XTrR-I, from Xenopus. XTrR-I (Xenopus transforming growth factor beta-related receptor type I) is expressed in all regions of embryos throughout early development. Overexpression of this receptor does not affect ectoderm or endoderm but dorsalizes the mesoderm such that muscle appears in ventral mesoderm and notochord appears in lateral mesoderm normally fated to become muscle. In addition, overexpression of XTrR-I in UV-treated embryos is able to cause formation of a partial dorsal axis. These results suggest that XTrR-I encodes a receptor which responds in normal development to a transforming growth factor beta-like ligand so as to promote dorsalization. Its function would therefore be to direct mesodermalized tissue into muscle or notochord.

PubMed ID: 7604016
PMC ID: PMC41540
Article link: Proc Natl Acad Sci U S A
Grant support: [+]

Species referenced: Xenopus
Genes referenced: tbxt tgfbr1

Article Images: [+] show captions
References [+] :
Altschul, Basic local alignment search tool. 1990, Pubmed