Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Interaction of the CCAAT displacement protein with shared regulatory elements required for transcription of paired histone genes.
el-Hodiri HM
,
Perry M
.
???displayArticle.abstract???
The H2A and H2B genes of the Xenopus xlh3 histone gene cluster are transcribed in opposite directions from initiation points located approximately 235 bp apart. The close proximity of these genes to one another suggests that their expression may be controlled by either a single bidirectional promoter or by separate promoters. Our analysis of the transcription of histone gene pairs containing deletions and site-specific mutations of intergenic DNA revealed that both promoters are distinct but that they overlap physically and share multiple regulatory elements, providing a possible basis for the coordinate regulation of their in vivo activities. Using the intergenic DNA fragment as a probe and extracts from mammalian and amphibian cells, we observed the formation of a specific complex containing the CCAAT displacement protein (CDP). The formation of the CDP-containing complex was not strictly dependent on any single element in the intergenic region but instead required the presence of at least two of the three CCAAT motifs. Interestingly, similar CDP-containing complexes were formed on the promoters from the three other histone genes. The binding of CDP to histone gene promoters may contribute to the coordination of their activities during the cell cycle and early development.
Ach,
Cooperation between CCAAT and octamer motifs in the distal sequence element of the rat U3 small nucleolar RNA promoter.
1991, Pubmed,
Xenbase
Ach,
Cooperation between CCAAT and octamer motifs in the distal sequence element of the rat U3 small nucleolar RNA promoter.
1991,
Pubmed
,
Xenbase
Andres,
Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development.
1992,
Pubmed
Andrés,
A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins.
1994,
Pubmed
Aufiero,
Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein.
1994,
Pubmed
Barberis,
Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter.
1987,
Pubmed
Blochlinger,
Patterns of expression of cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos.
1990,
Pubmed
Blochlinger,
Transformation of sensory organ identity by ectopic expression of Cut in Drosophila.
1991,
Pubmed
Blochlinger,
Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila.
1988,
Pubmed
Chellappan,
The E2F transcription factor is a cellular target for the RB protein.
1991,
Pubmed
Dufort,
The human cut homeodomain protein represses transcription from the c-myc promoter.
1994,
Pubmed
Gallinari,
Characterization and purification of H1TF2, a novel CCAAT-binding protein that interacts with a histone H1 subtype-specific consensus element.
1989,
Pubmed
Harada,
DNA-binding specificity of the cut repeats from the human cut-like protein.
1995,
Pubmed
Heikkilä,
Directional regulatory activity of cis-acting elements in the bidirectional alpha 1(IV) and alpha 2(IV) collagen gene promoter.
1993,
Pubmed
Heindl,
Promoter sequences required for transcription of Xenopus laevis histone genes in injected frog oocyte nuclei.
1988,
Pubmed
,
Xenbase
Heintz,
The regulation of histone gene expression during the cell cycle.
1991,
Pubmed
Hentschel,
The organization and expression of histone gene families.
1981,
Pubmed
Hinkley,
Histone H2B gene transcription during Xenopus early development requires functional cooperation between proteins bound to the CCAAT and octamer motifs.
1992,
Pubmed
,
Xenbase
Hinkley,
A variant octamer motif in a Xenopus H2B histone gene promoter is not required for transcription in frog oocytes.
1991,
Pubmed
,
Xenbase
Huh,
Presence of a bi-directional S phase-specific transcription regulatory element in the promoter shared by testis-specific TH2A and TH2B histone genes.
1991,
Pubmed
Jack,
Expression of the cut locus in the Drosophila wing margin is required for cell type specification and is regulated by a distant enhancer.
1991,
Pubmed
Lipson,
S-phase-specific regulation by deletion mutants of the human thymidine kinase promoter.
1989,
Pubmed
Liu,
Four distinct regulatory regions of the cut locus and their effect on cell type specification in Drosophila.
1991,
Pubmed
Maity,
Biochemical analysis of the B subunit of the heteromeric CCAAT-binding factor. A DNA-binding domain and a subunit interaction domain are specified by two separate segments.
1992,
Pubmed
Maxson,
Expression and organization of histone genes.
1983,
Pubmed
,
Xenbase
Neufeld,
Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut.
1992,
Pubmed
Old,
Individual Xenopus histone genes are replication-independent in oocytes and replication-dependent in Xenopus or mouse somatic cells.
1985,
Pubmed
,
Xenbase
Osley,
The regulation of histone synthesis in the cell cycle.
1991,
Pubmed
Pang,
A specific CCAAT-binding protein, CBP/tk, may be involved in the regulation of thymidine kinase gene expression in human IMR-90 diploid fibroblasts during senescence.
1993,
Pubmed
Peng,
Xenopus laevis: Practical uses in cell and molecular biology. Solutions and protocols.
1991,
Pubmed
,
Xenbase
Perry,
Genomic organization and nucleotide sequence of two distinct histone gene clusters from Xenopus laevis. Identification of novel conserved upstream sequence elements.
1985,
Pubmed
,
Xenbase
Perry,
Major transitions in histone gene expression do not occur during development in Xenopus laevis.
1986,
Pubmed
,
Xenbase
Rollins,
Morphogenesis and regulated gene activity are independent of DNA replication in Xenopus embryos.
1991,
Pubmed
,
Xenbase
Santoro,
A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs.
1988,
Pubmed
Skalnik,
CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.
1991,
Pubmed
Sturm,
Conservation of histone H2A/H2B intergene regions: a role for the H2B specific element in divergent transcription.
1988,
Pubmed
Valarché,
The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.
1993,
Pubmed
Woodland,
Histone synthesis during the development of Xenopus.
1980,
Pubmed
,
Xenbase
