XB-ART-19861Nature April 6, 1995; 374 (6522): 511-6.
Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation.
c-mos protein, encoded by a proto-oncogene, is essential for the meiotic maturation of frog oocytes. Polyadenylation of c-mos messenger RNA is shown here to be a pivotal regulatory step in meiotic maturation. Maturation is prevented by selective amputation of polyadenylation signals from c-mos mRNA. Injection of a prosthetic RNA, which restores c-mos polyadenylation signals by base pairing to the amputated mRNA, rescues maturation and can stimulate translation in trans. Prosthetic RNAs may provide a general strategy by which to alter patterns of mRNA expression in vivo.
PubMed ID: 7700377
Article link: Nature
Species referenced: Xenopus
Genes referenced: mos