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FEBS Lett April 3, 1995; 362 (2): 247-55.
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The arrestin superfamily: cone arrestins are a fourth family.

Craft CM , Whitmore DH .

Arrestins constitute a superfamily of regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. The potential role of arrestin in color visual processes led us to identify a cDNA encoding a cone-like arrestin in Xenopus laevis, the principle amphibian biological model system. Alignment of 18 deduced amino acid sequences of all known arrestins from both invertebrate and vertebrate species reveals five arrestin families. Further analysis identifies 7 variable and 4 conservative arrestin structural motifs that may identify potential functional domains. The adaptive evolutionary relationship of Xenopus cone arrestin to the arrestin gene tree suggests high intrafamily homology and early gene duplication events.

PubMed ID: 7720881
Article link: FEBS Lett
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: arrb1 arrb2