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Mech Dev April 1, 1995; 50 (2-3): 187-99.

Integrin alpha 5 during early development of Xenopus laevis.

Joos TO , Whittaker CA , Meng F , DeSimone DW , Gnau V , Hausen P .

The full length sequence of the Xenopus integrin alpha 5 subunit is reported. Analysis of cloned cDNA fragments reveals that alternative polyadenylation of alpha 5 mRNA occurs in the embryo. Furthermore, a variant form of the alpha 5 mRNA is expressed which encodes an integrin alpha 5 subunit with a truncated cytoplasmic domain. Integrin alpha 5 mRNA and protein are expressed in oocytes, eggs and throughout development. Spatial expression of alpha 5 mRNAs is first detected by whole mount in situ hybridization in presumptive neural crest cells and in the somitic mesoderm from the midgastrula stage onwards. In contrast, the alpha 5 protein is present on newly formed plasma membranes beginning at first cleavage. During neurulation, the integrin alpha 5 subunit disappears from the outer layer of the ectoderm, the notochord and the neural tube and accumulates in the sensorial layer of the ectoderm, the somites and the neural crest cells. These results provide evidence for the position specific regulation of alpha subunit expression in early vertebrate embryos.

PubMed ID: 7619730
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Species referenced: Xenopus laevis
Genes referenced: fn1 itga5 itgb1 mcf2 tbx2 xa-1
Antibodies: Itga5 Ab1 Itgb1 Ab1

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