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XB-ART-20807
Nature 1994 Sep 15;3716494:254-7. doi: 10.1038/371254a0.
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A cyclin associated with the CDK-activating kinase MO15.

Mäkelä TP , Tassan JP , Nigg EA , Frutiger S , Hughes GJ , Weinberg RA .


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The eukaryotic cell cycle is regulated by the sequential activation of cyclin-dependent kinases (CDKs). CDK activation is dependent on cyclin binding and phosphorylation of a conserved threonine (T161 in Cdc2) mediated by the CDK-activating kinase CAK. A CDK-related kinase, MO15 (ref. 10), has been identified as the catalytic subunit of CAK (refs 11-13). Here we use a yeast two-hybrid screen to show that a new human cyclin (cyclin H) is a MO15-associated protein. Cyclin H is a major MO15 partner in vivo and enhances the kinase activity of MO15 towards Cdk2/cyclin A. These findings demonstrate that a cyclin/kinase complex can function as a regulator of other cyclin/kinase complexes, and suggest that cyclin/kinase cascades may exist.

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Species referenced: Xenopus
Genes referenced: cdk7