Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
After fertilization in Xenopus laevis, inositol 1,4,5-trisphosphate (IP3) mass increased from 53 to 261 fmol/cell and returned to near basal by 10 min after insemination. IP3 was also elevated over control egg levels during first mitosis and first cleavage. Because IP3 levels and the fertilization calcium wave decline at about the same time and because calcium ionophore or pricking the egg increased IP3, the fertilization calcium wave may be due to calcium-induced IP3 production. In addition, the onset of sperm motility was associated with an increase, whereas the acrosomal reaction was accompanied by a decrease in IP3 mass. Combining our published data with this report, the first chronology of the levels of IP3 from the induction of meiosis (maturation) through fertilization and cleavage in one cellular system is summarized. These data suggest an in vivo dose response for IP3 and calcium release. A small (17 fmol/cell) IP3 change during the induction of meiosis may not be associated with a calcium change. Larger IP3 changes at cleavage (40 fmol/cell) and mitosis (125 fmol/cell) are associated with localized small calcium increases, whereas the largest IP3 change (208 fmol/cell) is associated with the large calcium increase at fertilization.
ALLEN,
The time sequence of early events in the fertilization of sea urchin eggs. I. The latent period and the cortical reaction.
1958, Pubmed
ALLEN,
The time sequence of early events in the fertilization of sea urchin eggs. I. The latent period and the cortical reaction.
1958,
Pubmed
Alonso,
Changes in triacylglycerol, diacylglycerol and free fatty acids after fertilization in developing toad embryos.
1986,
Pubmed
Baker,
Intracellular calcium and cell cleavage in early embryos of Xenopus laevis.
1972,
Pubmed
,
Xenbase
Busa,
An elevated free cytosolic Ca2+ wave follows fertilization in eggs of the frog, Xenopus laevis.
1985,
Pubmed
,
Xenbase
Busa,
Activation of frog (Xenopus laevis) eggs by inositol trisphosphate. I. Characterization of Ca2+ release from intracellular stores.
1985,
Pubmed
,
Xenbase
Busa,
Roles for the phosphatidylinositol cycle in early development.
1988,
Pubmed
Ciapa,
Two phases of inositol polyphosphate and diacylglycerol production at fertilisation.
1986,
Pubmed
Cicirelli,
Internal pH of Xenopus oocytes: a study of the mechanism and role of pH changes during meiotic maturation.
1983,
Pubmed
,
Xenbase
Clapper,
Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.
1987,
Pubmed
DeLisle,
Inositol trisphosphate is required for the propagation of calcium waves in Xenopus oocytes.
1992,
Pubmed
,
Xenbase
Fluck,
Slow calcium waves accompany cytokinesis in medaka fish eggs.
1991,
Pubmed
Forer,
The role of the phosphatidylinositol cycle in mitosis in sea urchin zygotes. Lithium inhibition is overcome by myo-inositol but not by other cyclitols or sugars.
1987,
Pubmed
Galione,
Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose.
1991,
Pubmed
Gerhart,
Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs.
1984,
Pubmed
,
Xenbase
Grandin,
Intracellular free calcium oscillates during cell division of Xenopus embryos.
1991,
Pubmed
,
Xenbase
Grandin,
The increase in intracellular pH associated with Xenopus egg activation is a Ca(2+)-dependent wave.
1992,
Pubmed
,
Xenbase
Grey,
An electrical block is required to prevent polyspermy in eggs fertilized by natural mating of Xenopus laevis.
1982,
Pubmed
,
Xenbase
Han,
Reducing inositol lipid hydrolysis, Ins(1,4,5)P3 receptor availability, or Ca2+ gradients lengthens the duration of the cell cycle in Xenopus laevis blastomeres.
1992,
Pubmed
,
Xenbase
Houle,
Intracellular pH plays a role in regulating protein synthesis in Xenopus oocytes.
1983,
Pubmed
,
Xenbase
Kamel,
Phosphatidylinositol metabolism during fertilization in the sea urchin egg.
1985,
Pubmed
Kline,
Calcium-dependent events at fertilization of the frog egg: injection of a calcium buffer blocks ion channel opening, exocytosis, and formation of pronuclei.
1988,
Pubmed
,
Xenbase
Kline,
Evidence for the involvement of a pertussis toxin-insensitive G-protein in egg activation of the frog, Xenopus laevis.
1991,
Pubmed
,
Xenbase
Kubota,
Free calcium wave upon activation in Xenopus eggs.
1987,
Pubmed
,
Xenbase
Larabell,
Inositol lipid hydrolysis contributes to the Ca2+ wave in the activating egg of Xenopus laevis.
1992,
Pubmed
,
Xenbase
Le Peuch,
Parthenogenetic activation decreases the polyphosphoinositide content of frog eggs.
1985,
Pubmed
,
Xenbase
Lechleiter,
Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes.
1992,
Pubmed
,
Xenbase
Maslanski,
Lithium-sensitive production of inositol phosphates during amphibian embryonic mesoderm induction.
1992,
Pubmed
,
Xenbase
McPherson,
Cortical localization of a calcium release channel in sea urchin eggs.
1992,
Pubmed
Miyazaki,
Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs.
1992,
Pubmed
Nuccitelli,
How do sperm activate eggs?
1991,
Pubmed
Parker,
Inhibition by Ca2+ of inositol trisphosphate-mediated Ca2+ liberation: a possible mechanism for oscillatory release of Ca2+.
1990,
Pubmed
,
Xenbase
Parys,
Isolation, characterization, and localization of the inositol 1,4,5-trisphosphate receptor protein in Xenopus laevis oocytes.
1992,
Pubmed
,
Xenbase
Picard,
Inositol 1,4,5-triphosphate microinjection triggers activation, but not meiotic maturation in amphibian and starfish oocytes.
1985,
Pubmed
,
Xenbase
Rakow,
Multiple stores of calcium are released in the sea urchin egg during fertilization.
1990,
Pubmed
Rink,
Free calcium in Xenopus embryos measured with ion-selective microelectrodes.
1980,
Pubmed
,
Xenbase
Steinhardt,
Activation of sea-urchin eggs by a calcium ionophore.
1974,
Pubmed
Stith,
Microinjection of inositol 1,2-(cyclic)-4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, and inositol 1,4,5-trisphosphate into intact Xenopus oocytes can induce membrane currents independent of extracellular calcium.
1989,
Pubmed
,
Xenbase
Stith,
Insulin and progesterone increase 32PO4-labeling of phospholipids and inositol 1,4,5-trisphosphate mass in Xenopus oocytes.
1992,
Pubmed
,
Xenbase
Swann,
The part played by inositol trisphosphate and calcium in the propagation of the fertilization wave in sea urchin eggs.
1986,
Pubmed
Swann,
Sperm-induced currents at fertilization in sea urchin eggs injected with EGTA and neomycin.
1992,
Pubmed
Turner,
Fertilization increases the polyphosphoinositide content of sea urchin eggs.
,
Pubmed
Turner,
Regulation of cortical vesicle exocytosis in sea urchin eggs by inositol 1,4,5-trisphosphate and GTP-binding protein.
1986,
Pubmed
Ubbels,
Evidence for a functional role of the cytoskeleton in determination of the dorsoventral axis in Xenopus laevis eggs.
1983,
Pubmed
,
Xenbase
Webb,
Direct measurement of intracellular pH changes in Xenopus eggs at fertilization and cleavage.
1981,
Pubmed
,
Xenbase
Webb,
Fertilization potential and electrical properties of the Xenopus laevis egg.
1985,
Pubmed
,
Xenbase
Whitaker,
Calcium-dependent polyphosphoinositide hydrolysis is associated with exocytosis in vitro.
1985,
Pubmed
Whitaker,
Calcium and cell cycle control.
1990,
Pubmed
Wolf,
A molecular approach to fertilization. II. Viability and artificial fertilization of Xenopus laevis gemetes.
1971,
Pubmed
,
Xenbase
Wolf,
The cortical response in Xenopus laevis ova.
1974,
Pubmed
,
Xenbase
Wolf,
A molecular approach to fertilization. 3. Development of a bioassay for sperm capacitation.
1971,
Pubmed
