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Nucleic Acids Res
1993 Mar 11;215:1193-8. doi: 10.1093/nar/21.5.1193.
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The pre-mRNA binding K protein contains a novel evolutionarily conserved motif.
Siomi H
,
Matunis MJ
,
Michael WM
,
Dreyfuss G
.
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The K protein is among the major pre-mRNA-binding proteins (hnRNPs) in vertebrate cell nuclei. It binds tenaciously to cytidine-rich sequences and is the major oligo(rC/dC)-binding protein in vertebrate cells. We have cloned a cDNA of the Xenopus laevis hnRNP K and determined its sequence. The X.laevis hnRNP K is a 47 kD protein that is remarkably similar to its human 66 kD counterpart except for two large internal deletions. The sequence of hnRNP K contains a 45 amino acid repeated motif which is almost completely conserved between the X.laevis and human proteins. We found that this repeated motif, the KH motif (for K homology), shows significant homology to several proteins some of which are known nucleic acids binding proteins. The homology is particularly strong with the archeabacterial ribosomal protein S3 and with the saccharomyces cerevisiae protein MER1 which is required for meiosis-specific splicing of the MER 2 transcript. As several of the proteins that contain the KH motif are known to bind RNA, this domain may be involved in RNA binding.
Bandziulis,
RNA-binding proteins as developmental regulators.
1989, Pubmed
Bandziulis,
RNA-binding proteins as developmental regulators.
1989,
Pubmed
Brauer,
The primary structure of protein S3 from the small ribosomal subunit of Escherichia coli.
1979,
Pubmed
Choi,
Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells.
1984,
Pubmed
Choi,
Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly.
1984,
Pubmed
Christensen,
The nucleolar protein, B-36, contains a glycine and dimethylarginine-rich sequence conserved in several other nuclear RNA-binding proteins.
1988,
Pubmed
Chung,
Set of novel, conserved proteins fold pre-messenger RNA into ribonucleosomes.
1986,
Pubmed
Delahodde,
A yeast protein HX has homologies with the histone H2AF expressed in chicken embryo.
1986,
Pubmed
Dreyfuss,
Structure and function of nuclear and cytoplasmic ribonucleoprotein particles.
1986,
Pubmed
Dreyfuss,
Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation.
1988,
Pubmed
Dreyfuss,
Physical change in cytoplasmic messenger ribonucleoproteins in cells treated with inhibitors of mRNA transcription.
1984,
Pubmed
Dreyfuss,
Characterization of heterogeneous nuclear RNA-protein complexes in vivo with monoclonal antibodies.
1984,
Pubmed
Engebrecht,
Meiosis-specific RNA splicing in yeast.
1991,
Pubmed
Engebrecht,
MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis.
1990,
Pubmed
Engebrecht,
Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation.
1990,
Pubmed
Feng,
Progressive sequence alignment as a prerequisite to correct phylogenetic trees.
1987,
Pubmed
Frankel,
RNA-protein interactions.
1991,
Pubmed
Kenan,
RNA recognition: towards identifying determinants of specificity.
1991,
Pubmed
Matunis,
Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein.
1992,
Pubmed
Möller,
Phosphate-binding sequences in nucleotide-binding proteins.
1985,
Pubmed
O'Farrell,
High resolution two-dimensional electrophoresis of basic as well as acidic proteins.
1977,
Pubmed
Pearson,
Rapid and sensitive sequence comparison with FASTP and FASTA.
1990,
Pubmed
Piñol-Roma,
Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins.
1988,
Pubmed
Piñol-Roma,
Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm.
1992,
Pubmed
,
Xenbase
Piñol-Roma,
A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts.
1989,
Pubmed
Rinke-Appel,
The path of mRNA through the Escherichia coli ribosome; site-directed cross-linking of mRNA analogues carrying a photo-reactive label at various points 3' to the decoding site.
1991,
Pubmed
Régnier,
Nucleotide sequence of the pnp gene of Escherichia coli encoding polynucleotide phosphorylase. Homology of the primary structure of the protein with the RNA-binding domain of ribosomal protein S1.
1987,
Pubmed
Saraste,
The P-loop--a common motif in ATP- and GTP-binding proteins.
1990,
Pubmed
Spiridonova,
Ribosomal protein gene cluster of Halobacterium halobium: nucleotide sequence of the genes coding for S3 and L29 equivalent ribosomal proteins.
1989,
Pubmed
Swanson,
Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities.
1988,
Pubmed
