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Nature March 11, 1993; 362 (6416): 127-33.

Primary structure and functional expression of a mouse inward rectifier potassium channel.

Kubo Y , Baldwin TJ , Jan YN , Jan LY .

A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.

PubMed ID: 7680768
Article link: Nature

Species referenced: Xenopus
Genes referenced: kcnj12 kcnj2

References :
Aldrich, Potassium channels. Advent of a new family. 1993, Pubmed, Xenbase