Dev Biol 1992 Jul 01;1521:194-8. doi: 10.1016/0012-1606(92)90170-l.

Identification and developmental expression of Src+ mRNAs in Xenopus laevis.

???displayArticle.abstract???
Alternative splicing of src mRNA has been demonstrated in several vertebrate species to yield a neuron-specific form of src protein termed pp60+. The function of pp60+ is unknown. The early developmental expression pattern of src+ RNA has not been previously examined. We have identified and characterized src+ transcripts corresponding to the two src genes in Xenopus laevis using a reverse transcription/polymerase chain reaction (RT/PCR) method. Both Xenopus pp60+ proteins have a 5-amino-acid insert in contrast to the 6-amino-acid insert in fish, birds, and mammals. Src+ mRNA first appears in neural plate stage Xenopus embryos, after neural induction signaling events but prior to neural differentiation. Analysis of dissected neural plate stage embryos showed that src+ mRNAs are localized to the neural plate. These findings suggest that pp60+ may play a role in elaboration of neuron structure.

???displayArticle.pubmedLink??? 1378412
???displayArticle.link??? Dev Biol


Species referenced: Xenopus laevis
Genes referenced: src