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XB-ART-23633
Cell 1992 Jun 26;697:1097-106.
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Gastrulation in the mouse: the role of the homeobox gene goosecoid.

Blum M , Gaunt SJ , Cho KW , Steinbeisser H , Blumberg B , Bittner D , De Robertis EM .


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Mouse goosecoid is a homeobox gene expressed briefly during early gastrulation. Its mRNA accumulates as a patch on the side of the epiblast at the site where the primitive streak is first formed. goosecoid-expressing cells are then found at the anterior end of the developing primitive streak, and finally in the anteriormost mesoderm at the tip of the early mouse gastrula, a region that gives rise to the head process. Treatment of early mouse embryos with activin results in goosecoid mRNA accumulation in the entire epiblast, suggesting that a localized signal induces goosecoid expression during development. Transplantation experiments indicate that the tip of the murine early gastrula is the equivalent of the organizer of the amphibian gastrula.

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Species referenced: Xenopus
Genes referenced: gsc