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XB-ART-23683
Development June 1, 1992; 115 (2): 639-47.

DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.

Jones CM , Lyons KM , Lapan PM , Wright CV , Hogan BL .


Abstract
Establishment of mesodermal tissues in the amphibian body involves a series of inductive interactions probably elicited by a variety of peptide growth factors. Results reported here suggest that mesodermal patterning involves an array of signalling molecules including DVR-4, a TGF-beta-like molecule. We show that ectopic expression of DVR-4 causes embryos to develop with an overall posterior and/or ventral character, and that DVR-4 induces ventral types of mesoderm in animal cap explants. Moreover, DVR-4 overrides the dorsalizing effects of activin. DVR-4 is therefore the first molecule reported both to induce posteroventral mesoderm and to counteract dorsalizing signals such as activin. Possible interactions between these molecules resulting in establishment of the embryonic body plan are discussed.

PubMed ID: 1425343
Article link: Development
Grant support: [+]

Species referenced: Xenopus
Genes referenced: actc1 bmp4 evx1 tbxt tgfb1 wnt8a