XB-ART-24375
Biochem Biophys Res Commun
1991 Nov 14;1803:1460-8.
Show Gene links
Show Anatomy links
The orphan receptor cDNA RDC4 encodes a 5-HT1D serotonin receptor.
???displayArticle.abstract???
The cDNA of RDC4, a putative receptor of the G protein-coupled receptor family, has been cloned by PCR methodology. The primary structure of this receptor showed homology with the serotonin 5-HT1A receptor. In this work, RDC4 mRNA has been injected in Y1 adrenal cells and Xenopus oocytes and RDC4 cDNA has been transfected transiently in cos-7 cells. In all these systems serotonin elicited a rise in cyclic AMP levels. Binding studies on membranes of the transfected cos-7 cells using [3H]-LSD showed a pattern of drug affinities consistent with the known properties of a 5-HT1D receptor. RDC4 therefore codes for a 5-HT1D receptor which in the studied systems is positively coupled to adenylate cyclase.
???displayArticle.pubmedLink??? 1659418
???displayArticle.link??? Biochem Biophys Res Commun
Species referenced: Xenopus
Genes referenced: htr1a