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XB-ART-24642
Neuron August 1, 1991; 7 (2): 295-307.
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The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors.

Takagi S , Hirata T , Agata K , Mochii M , Eguchi G , Fujisawa H .


Abstract
The A5 antigen is a neuronal cell surface protein of Xenopus presumed to be involved in the neuronal recognition between the optic nerve fibers and the visual centers. Analyses of cDNA clones revealed that the A5 antigen is a class I membrane protein containing two different internal repeats in the extracellular segment. The first repeat bears homology to domain III of complement components C1r and C1s, and the second repeat is homologous to the C1 and C2 domains of coagulation factors V and VIII. The mRNA for the A5 antigen was present in retinal ganglion cells and visual center neurons. Nonneuronal cells in the peripheral and central nervous systems did not express the mRNA for the A5 antigen.

PubMed ID: 1908252
Article link: Neuron


Species referenced: Xenopus
Genes referenced: c1r c1s nrp1
Antibodies: Nrp1 Ab1