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XB-ART-24724
Dev Biol 1991 Jul 01;1461:250-4. doi: 10.1016/0012-1606(91)90466-g.
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Coordinate inactivation of class III genes during the Gastrula-Neurula Transition in Xenopus.

Andrews MT , Loo S , Wilson LR .


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We have identified a period during early Xenopus development when several different genes transcribed by RNA polymerase III (class III genes) are coordinately inactivated. During the late gastrula stage a major reduction in the number of active transcription complexes gives rise to a pattern of class III gene activity typical of adult somatic cells. This event is referred to as the Gastrula-Neurula Transition and involves the inactivation of genes encoding oocyte-type tRNAs and 5S RNA, along with several heterogeneous RNAs expressed during the blastula and gastrula stages of embryogenesis.

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