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XB-ART-25128
Nature 1991 Jan 24;3496307:305-10. doi: 10.1038/349305a0.
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Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence.

Papazian DM , Timpe LC , Jan YN , Jan LY .


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Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.

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