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We describe the cloning and characterization of two cDNAs from Xenopus laevis that encode sequence-specific DNA binding proteins called FRG Y1 and FRG Y2 (frog Y-box proteins 1 and 2). During oogenesis and embryogenesis, the genes encoding these proteins are differentially expressed. FRG Y1 mRNA is present in oocytes, embryos, and all adult tissues examined, whereas FRG Y2 mRNA is found only in testis and immature oocytes. The FRG Y1 and FRG Y2 proteins are shown to stimulate transcription from a promoter containing a Y box (CTGATTGGCCAA). This promoter element is found in both mammalian major histocompatibility complex class II and Xenopus germ-cell-specific genes. FRG Y1, FRG Y2, and a human Y-box binding protein are homologous and represent a distinct family of sequence-specific DNA binding proteins. We identify protamine-like regions that are present within this family of transcription factors, suggesting that they use unusual means of binding to DNA.
Almouzni,
Competition between transcription complex assembly and chromatin assembly on replicating DNA.
1990, Pubmed,
Xenbase
Almouzni,
Competition between transcription complex assembly and chromatin assembly on replicating DNA.
1990,
Pubmed
,
Xenbase
Barberis,
Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter.
1987,
Pubmed
Bendig,
Fidelity of transcription of Xenopus laevis globin genes injected into Xenopus laevis oocytes and unfertilized eggs.
1984,
Pubmed
,
Xenbase
Bienz,
Developmental control of the heat shock response in Xenopus.
1984,
Pubmed
,
Xenbase
Bienz,
Xenopus hsp 70 genes are constitutively expressed in injected oocytes.
1984,
Pubmed
,
Xenbase
Bienz,
Heat shock regulatory elements function as an inducible enhancer in the Xenopus hsp70 gene and when linked to a heterologous promoter.
1986,
Pubmed
,
Xenbase
Bienz,
A CCAAT box confers cell-type-specific regulation on the Xenopus hsp70 gene in oocytes.
1986,
Pubmed
,
Xenbase
Chirgwin,
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
1979,
Pubmed
Didier,
Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.
1988,
Pubmed
Ginsberg,
Xenopus 5S gene transcription factor, TFIIIA: characterization of a cDNA clone and measurement of RNA levels throughout development.
1984,
Pubmed
,
Xenbase
Goldstein,
Major cold shock protein of Escherichia coli.
1990,
Pubmed
Graves,
Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene.
1986,
Pubmed
Hahn,
The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts.
1988,
Pubmed
Hwang,
Characterization of the S-phase-specific transcription regulatory elements in a DNA replication-independent testis-specific H2B (TH2B) histone gene.
1990,
Pubmed
Johnson,
Sequence homologies in the mouse protamine 1 and 2 genes.
1988,
Pubmed
Landschulz,
Isolation of a recombinant copy of the gene encoding C/EBP.
1988,
Pubmed
Lewis,
An erythrocyte-specific protein that binds to the poly(dG) region of the chicken beta-globin gene promoter.
1988,
Pubmed
Lohka,
Formation in vitro of sperm pronuclei and mitotic chromosomes induced by amphibian ooplasmic components.
1983,
Pubmed
,
Xenbase
Lund,
In vitro synthesis of vertebrate U1 snRNA.
1989,
Pubmed
,
Xenbase
McKnight,
Expression of the herpes thymidine kinase gene in Xenopus laevis oocytes: an assay for the study of deletion mutants constructed in vitro.
1980,
Pubmed
,
Xenbase
McKnight,
Transcriptional control signals of a eukaryotic protein-coding gene.
1982,
Pubmed
Mohun,
An amphibian cytoskeletal-type actin gene is expressed exclusively in muscle tissue.
1987,
Pubmed
,
Xenbase
Norman,
Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.
1988,
Pubmed
Pinkham,
Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator.
1987,
Pubmed
Rio,
SV40 T antigen binding site mutations that affect autoregulation.
1983,
Pubmed
Rosenfeld,
Purification of nuclear factor I by DNA recognition site affinity chromatography.
1986,
Pubmed
Sakura,
Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology.
1988,
Pubmed
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Santoro,
A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs.
1988,
Pubmed
Scotto,
Positive and negative regulation of the gene for transcription factor IIIA in Xenopus laevis oocytes.
1989,
Pubmed
,
Xenbase
Taylor,
The developmental expression of the gene for TFIIIA in Xenopus laevis.
1986,
Pubmed
,
Xenbase
Tso,
Structure of the gene for Xenopus transcription factor TFIIIA.
1986,
Pubmed
,
Xenbase
Vinson,
In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage.
1988,
Pubmed
Vriz,
Differential expression of two Xenopus c-myc proto-oncogenes during development.
1989,
Pubmed
,
Xenbase
Warrant,
alpha-Helix-double helix interaction shown in the structure of a protamine-transfer RNA complex and a nucleoprotamine model.
1978,
Pubmed
Wistow,
Cold shock and DNA binding.
1990,
Pubmed
