Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-25502
Neuron 1990 Nov 01;55:583-95.
Show Gene links Show Anatomy links

Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development.

Bettler B , Boulter J , Hermans-Borgmeyer I , O'Shea-Greenfield A , Deneris ES , Moll C , Borgmeyer U , Hollmann M , Heinemann S .


???displayArticle.abstract???
We have isolated cDNAs encoding a glutamate receptor subunit, designated GluR5, displaying 40%-41% amino acid identity with the kainate/AMPA receptor subunits GluR1, GluR2, GluR3, and GluR4. This level of sequence similarity is significantly below the approximately 70% intersubunit identity characteristic of kainate/AMPA receptors. The GluR5 protein forms homomeric ion channels in Xenopus oocytes that are weakly responsive to L-glutamate. The GluR5 gene is expressed in subsets of neurons throughout the developing and adult central and peripheral nervous systems. During embryogenesis, GluR5 transcripts are detected in areas of neuronal differentiation and synapse formation.

???displayArticle.pubmedLink??? 1977421
???displayArticle.link??? Neuron
???displayArticle.grants??? [+]

Species referenced: Xenopus
Genes referenced: gria1 gria2 gria3 gria4 grik1