Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-26005
Biochem Biophys Res Commun March 16, 1990; 167 (2): 784-9.

Expression of the brown fat mitochondria uncoupling protein in Xenopus oocytes and important into mitochondrial membrane.

Klaus S , Casteilla L , Bouillaud F , Raimbault S , Ricquier D .


Abstract
Non shivering thermogenesis of brown adipose tissue is due to the uncoupling protein (UCP), located in the inner mitochondrial membrane, which functions as a proton translocator and can thus uncouple mitochondrial respiration. We describe here the expression of UCP in Xenopus laevis oocytes after injection of UCP mRNA, which was transcribed in vitro. UCP seems to be correctly transported into mitochondria and integrated into the membrane, but we were not able to establish definitely the functionality of this UCP. We conclude that this expression system could be suitable for the study of the mitochondrial import mechanism but not for the examination of physiological properties of UCP.

PubMed ID: 2322252
Article link: Biochem Biophys Res Commun


Species referenced: Xenopus
Genes referenced: ucp1