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EMBO J
1989 Nov 01;811:3235-44. doi: 10.1002/j.1460-2075.1989.tb08483.x.
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Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.
Stühmer W
,
Ruppersberg JP
,
Schröter KH
,
Sakmann B
,
Stocker M
,
Giese KP
,
Perschke A
,
Baumann A
,
Pongs O
.
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Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization of the channels expressed in Xenopus laevis oocytes following microinjection of in vitro transcribed RCK-specific RNAs shows that each of the RCK proteins forms K+ channels that differ greatly in both their functional and pharmacological properties. This suggests that the molecular basis for the diversity of voltage-gated K+ channels in mammalian brain is based, at least partly, on the expression of several RCK proteins by a family of genes and their assembly to homooligomeric K+ channels with different functional properties.
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