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Nature May 25, 1989; 339 (6222): 280-6.

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity.

Murray AW , Solomon MJ , Kirschner MW .

We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in vivo and in vitro. We have used a fractionated extract to study the activation of MPF by added cyclin protein.

PubMed ID: 2566918
Article link: Nature