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XB-ART-26889
Drug Chem Toxicol 1989 Mar 01;121:67-75. doi: 10.3109/01480548908999144.
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Developmental toxicity testing with FETAX: evaluation of five compounds.

Dawson DA , Fort DJ , Newell DL , Bantle JA .


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The teratogenic potential of five compounds was evaluated with FETAX (Frog Embryo Teratogenesis Assay: Xenopus). Early embryos of Xenopus laevis were exposed for 96 h to 6-aminonicotinamide (6-AN), isoniazid (INH), urethane, nitrilotriacetate (NTA) or sodium cyclamate, in two separate static-renewal tests of each compound. Based on Teratogenic Index values, growth endpoints and the types and severity of the induced malformations, 6-AN, INH and urethane scored as having strong teratogenic potential. NTA and sodium cyclamate had little or no teratogenic potential. The results support continued evaluation of FETAX as a screening assay for chemical teratogens.

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