XB-ART-27253Nature October 6, 1988; 335 (6190): 519-25.
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.
The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression of pp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.
PubMed ID: 2971141
Article link: Nature
Species referenced: Xenopus
Genes referenced: mos