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J Virol
1988 Oct 01;6210:3903-6. doi: 10.1128/JVI.62.10.3903-3906.1988.
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Two distinct regions of the murine p53 primary amino acid sequence are implicated in stable complex formation with simian virus 40 T antigen.
Jenkins JR
,
Chumakov P
,
Addison C
,
Stürzbecher HW
,
Wade-Evans A
.
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We mapped regions of the mouse p53 primary amino acid sequence implicated in stable complex formation with simian virus 40 T antigen. A number of mutant p53 proteins failed to complex stably with T antigen in vivo but formed stable complexes with T antigen in in vitro association assays. In contrast to an earlier report (T.-H. Tan, H. Wallis, and A. J. Levine, J. Virol. 59:574-583, 1986), our study showed that two distinct regions of p53 primary amino acid sequence, highly conserved between mouse and Xenopus laevis, were implicated in stable complex formation. Our data support the proposal that, when in complex, T antigen may occupy a site on p53 that is implicated in the normal function of the protein.
Braithwaite,
Mouse p53 inhibits SV40 origin-dependent DNA replication.
, Pubmed
Braithwaite,
Mouse p53 inhibits SV40 origin-dependent DNA replication.
,
Pubmed
Carroll,
Time-dependent maturation of the simian virus 40 large T antigen-p53 complex studied by using monoclonal antibodies.
1982,
Pubmed
DeLeo,
Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.
1979,
Pubmed
Eliyahu,
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells.
,
Pubmed
Gannon,
p53 and DNA polymerase alpha compete for binding to SV40 T antigen.
,
Pubmed
Harlow,
Complex of simian virus 40 large-T antigen and host 53,000-molecular-weight protein in monkey cells.
1981,
Pubmed
Harlow,
Monoclonal antibodies specific for simian virus 40 tumor antigens.
1981,
Pubmed
Hinds,
Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines.
1987,
Pubmed
Jenkins,
Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53.
,
Pubmed
Jenkins,
The cellular oncogene p53 can be activated by mutagenesis.
,
Pubmed
Lane,
T antigen is bound to a host protein in SV40-transformed cells.
1979,
Pubmed
Linzer,
Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells.
1979,
Pubmed
McCormick,
SV40 T antigen binds specifically to a cellular 53 K protein in vitro.
1981,
Pubmed
Parada,
Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.
,
Pubmed
Rovinski,
Deletion of 5'-coding sequences of the cellular p53 gene in mouse erythroleukemia: a novel mechanism of oncogene regulation.
1987,
Pubmed
Rovinski,
Immortalization of rat embryo fibroblasts by the cellular p53 oncogene.
1988,
Pubmed
Sarnow,
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells.
1982,
Pubmed
Soussi,
Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53.
1987,
Pubmed
,
Xenbase
Stürzbecher,
Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.
1987,
Pubmed
Stürzbecher,
Characterization of mutant p53-hsp72/73 protein-protein complexes by transient expression in monkey COS cells.
1988,
Pubmed
Tan,
Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex.
1986,
Pubmed
Wade-Evans,
Precise epitope mapping of the murine transformation-associated protein, p53.
1985,
Pubmed
Yewdell,
Monoclonal antibody analysis of p53 expression in normal and transformed cells.
1986,
Pubmed
Zantema,
Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells.
1985,
Pubmed
