Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Inositol trisphosphate-induced membrane potential oscillations in Xenopus oocytes.
Berridge MJ
.
???displayArticle.abstract???
1. The role of inositol 1,4,5-trisphosphate (Ins1,4,5P3) in controlling the membrane potential oscillations induced by acetylcholine in Xenopus oocytes was investigated by studying the effect of injecting Ins1,4,5P3. 2. Perfusing Xenopus oocytes with low concentrations of acetylcholine (less than or equal to 1 x 10(-7) M) induced regular oscillations in membrane potential. The frequency of these oscillations accelerated as the concentration of acetylcholine was increased. 3. Ionophoretic application of low doses of Ins1,4,5P3 stimulated membrane depolarization in the form of an initial brief spike which was followed by a burst of oscillations when the amount of Ins1,4,5P3 injected was increased. 4. When low doses of Ins1,4,5P3 were injected at 30 s intervals, there was rapid desensitization of the early response which recovered if the interval between injections was extended to 2 min or longer. 5. In comparison to the vegetal pole, the animal pole was much more sensitive to Ins1,4,5P3. This localization of Ins1,4,5P3 sensitivity in the animal pole may contribute to the electrical field which surrounds Xenopus oocytes. 6. A model is presented to explain these oscillations based on the phenomenon of calcium-induced calcium release. It is proposed that Ins1,4,5P3 releases calcium from an Ins1,4,5P3-sensitive pool which is then periodically taken up and released by an Ins1,4,5P3-insensitive pool. It is the overloading of this Ins1,4,5P3-insensitive pool which may provide the trigger to spontaneously release calcium back into the cytoplasm.
Benham,
Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of the rabbit.
1986, Pubmed
Benham,
Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of the rabbit.
1986,
Pubmed
Berridge,
Inositol trisphosphate, a novel second messenger in cellular signal transduction.
,
Pubmed
Berridge,
Inositol trisphosphate and diacylglycerol: two interacting second messengers.
1987,
Pubmed
Biden,
Inositol 1,4,5-trisphosphate and intracellular Ca2+ homeostasis in clonal pituitary cells (GH3). Translocation of Ca2+ into mitochondria from a functionally discrete portion of the nonmitochondrial store.
1986,
Pubmed
Capiod,
Internal perfusion of guinea-pig hepatocytes with buffered Ca2+ or inositol 1,4,5-trisphosphate mimics noradrenaline activation of K+ and Cl- conductances.
1987,
Pubmed
Cuthbertson,
Phorbol ester and sperm activate mouse oocytes by inducing sustained oscillations in cell Ca2+.
,
Pubmed
Dascal,
Role of calcium mobilization in mediation of acetylcholine-evoked chloride currents in Xenopus laevis oocytes.
1985,
Pubmed
,
Xenbase
Evans,
Potentiation of muscarinic and alpha-adrenergic responses by an analogue of guanosine 5'-triphosphate.
1986,
Pubmed
Fabiato,
Contractions induced by a calcium-triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells.
1975,
Pubmed
Gillo,
The involvement of inositol 1,4,5-trisphosphate and calcium in the two-component response to acetylcholine in Xenopus oocytes.
1987,
Pubmed
,
Xenbase
Hirono,
Neurotensin and acetylcholine evoke common responses in frog oocytes injected with rat brain messenger ribonucleic acid.
1987,
Pubmed
,
Xenbase
Igusa,
Periodic increase of cytoplasmic free calcium in fertilized hamster eggs measured with calcium-sensitive electrodes.
1986,
Pubmed
Kuba,
Rhythmic hyperpolarizations and depolarization of sympathetic ganglion cells induced by caffeine.
1976,
Pubmed
Kusano,
Cholinergic and catecholaminergic receptors in the Xenopus oocyte membrane.
1982,
Pubmed
,
Xenbase
MacVicar,
Membrane conductance oscillations in astrocytes induced by phorbol ester.
,
Pubmed
Miledi,
Properties of acetylcholine receptors translated by cat muscle mRNA in Xenopus oocytes.
1982,
Pubmed
,
Xenbase
Miledi,
Chloride current induced by injection of calcium into Xenopus oocytes.
1984,
Pubmed
,
Xenbase
Neher,
Fast calcium transients in rat peritoneal mast cells are not sufficient to trigger exocytosis.
1986,
Pubmed
Nomura,
Inositol phosphate formation and chloride current responses induced by acetylcholine and serotonin through GTP-binding proteins in Xenopus oocyte after injection of rat brain messenger RNA.
1987,
Pubmed
,
Xenbase
Oron,
Inositol 1,4,5-trisphosphate mimics muscarinic response in Xenopus oocytes.
,
Pubmed
,
Xenbase
Palade,
Spontaneous calcium release from sarcoplasmic reticulum. General description and effects of calcium.
1983,
Pubmed
Parker,
Intracellular Ca2+-dependent and Ca2+-independent responses of rat brain serotonin receptors transplanted to Xenopus oocytes.
1985,
Pubmed
,
Xenbase
Parker,
Changes in intracellular calcium and in membrane currents evoked by injection of inositol trisphosphate into Xenopus oocytes.
1986,
Pubmed
,
Xenbase
Parker,
Activation of a common effector system by different brain neurotransmitter receptors in Xenopus oocytes.
1987,
Pubmed
,
Xenbase
Robinson,
Electrical currents through full-grown and maturing Xenopus oocytes.
1979,
Pubmed
,
Xenbase
Sauvé,
Oscillatory activation of calcium-dependent potassium channels in HeLa cells induced by histamine H1 receptor stimulation: a single-channel study.
1987,
Pubmed
Ueda,
Oscillations of cytoplasmic concentrations of Ca2+ and K+ in fused L cells.
1986,
Pubmed
Woods,
Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes.
,
Pubmed
Woods,
Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes.
1987,
Pubmed
Yada,
Synchronous oscillation of the cytoplasmic Ca2+ concentration and membrane potential in cultured epithelial cells (Intestine 407).
1986,
Pubmed
