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XB-ART-27675
Proc Natl Acad Sci U S A 1988 Feb 01;853:910-3.
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Antimicrobial activity of synthetic magainin peptides and several analogues.

Zasloff M , Martin B , Chen HC .


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We have previously reported the isolation of two broad-spectrum antimicrobial peptides ("magainins") from the skin of the African clawed frog Xenopus laevis. These natural peptides are active against many species of bacteria and fungi and also induce osmotic lysis of protozoa. In this report we demonstrate that synthetic magainin peptides appear to be indistinguishable from the natural products with respect to chromatographic properties and biological activity. These studies demonstrate conclusively that the magainin peptides are potent antimicrobial substances.

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Species referenced: Xenopus laevis
Genes referenced: magainins

References [+] :
Andreu, Solid-phase synthesis of PYLa and isolation of its natural counterpart, PGLa [PYLa-(4-24)] from skin secretion of Xenopus laevis. 1985, Pubmed, Xenbase