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EMBO J
1987 Mar 01;63:667-73. doi: 10.1002/j.1460-2075.1987.tb04806.x.
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Xenopus cytoskeletal actin and human c-fos gene promoters share a conserved protein-binding site.
Mohun T
,
Garrett N
,
Treisman R
.
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Xenopus laevis cytoskeletal actin gene promoters contain a 20-bp sequence homologous to the serum response element (SRE) required for transient human c-fos gene transcription in response to serum factors. Both sequences bind the same factor in HeLa cell extracts, as shown by binding competition, DNase I and dimethylsulphate (DMS) protection and DMS interference assays. A similar protein is present in Xenopus laevis oocytes. Sequences containing the SRE homology are essential for constitutive activity of the actin promoter in both Xenopus and mouse cells, and a synthetic SRE functions as a promoter element in these cells. In mouse cells, transcription of both transfected Xenopus actin and actin/c-fos fusion genes is activated following serum stimulation. These data suggest that the SRE and its cognate protein form part of a regulatory pathway that has been highly conserved during evolution.
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Bienz,
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,
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Curran,
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Curran,
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Curran,
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Deschamps,
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Dignam,
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Dignam,
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,
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Dudler,
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,
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Dynan,
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Efstratiadis,
The structure and evolution of the human beta-globin gene family.
1980,
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Elder,
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1984,
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Fried,
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.
1981,
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Garner,
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Gorman,
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
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Greenberg,
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,
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Greenberg,
Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.
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Herr,
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,
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Herr,
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Johnsrud,
Contacts between Escherichia coli RNA polymerase and a lac operon promoter.
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Kost,
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Kruijer,
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,
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Lau,
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Minty,
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Mitchell,
Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation.
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Mohun,
Cell type-specific activation of actin genes in the early amphibian embryo.
,
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,
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Mohun,
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,
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Müller,
Induction of c-fos gene and protein by growth factors precedes activation of c-myc.
,
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Nakajima-Iijima,
Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.
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Nudel,
The nucleotide sequence of the rat cytoplasmic beta-actin gene.
1983,
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Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
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Siebenlist,
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Strauss,
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Treisman,
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Treisman,
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Vandekerckhove,
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,
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Verma,
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Zullo,
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