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Dev Dyn December 1, 2004; 231 (4): 671-82.
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Implication of bax in Xenopus laevis tail regression at metamorphosis.

Sachs LM , Le Mevel S , Demeneix BA .

Apoptosis is fundamental to normal vertebrate development. A dramatic example of postembryonic development involving apoptosis is tail regression during amphibian metamorphosis. Earlier studies led us to propose a functional role for the pro-apoptotic protein Bax in tadpole tail regression. However, its physiological relevance has never been analyzed. We have now cloned a cDNA encoding Xenopus laevis bax (xlbax) and used in vivo gene transfer in tail muscle to analyze the effects of xlbax overexpression. Furthermore, by using an antisense strategy in a similar experimental paradigm, xlbax antisense mRNA was shown to block the apoptotic effects of xlbax and protect against apoptosis in metamorphosing tadpoles. Our results suggest that xlbax is a regulator of muscle fiber death in the regressing tail during metamorphosis.

PubMed ID: 15497139
Article link: Dev Dyn

Species referenced: Xenopus laevis
Genes referenced: bax bcl2l1 hopx rpl8

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