Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Myoblasts and myoblast-conditioned medium attract the earliest spinal neurites from frog embryos.
McCaig CD
.
???displayArticle.abstract???
A study was made of the capacity of newly segmented somites, unsegmented mesoderm and medium conditioned by each of these tissues to attract the growth of the earliest spinal neurites from the neural tube of Xenopus laevis in tissue culture. When presented with segmented somitic myoblasts or sheets of skin, spinal neurites grew selectively towards the somitic myoblasts. Neurites were not attracted specifically to somitic myoblasts from their own rostrocaudal level. A variable proportion of myoblasts from unsegmented caudal mesoderm differentiated and elongated in co-culture with neural tube and skin. These myoblasts also attracted neural outgrowths, but only if present in sufficient numbers. An agar slab containing medium conditioned by the presence of segmented myoblasts for 1 day attracted neurite outgrowths. A source of medium conditioned by the presence of undifferentiated, unsegmented myotomal mesoderm alone did not attract neurite outgrowths. Nerve growth factor (NGF) at a range of concentrations in the agar source (500-10,000 ng/ml) did not attract the earliest neurite outgrowths. It is concluded that the earliest skeletal myoblasts from Xenopus laevis embryos may attract neural outgrowths by releasing a soluble factor. Myoblasts may have to develop to the stage of somite segmentation before secretion of such an agent begins. The release of a myoblast-derived factor so early in development may assist directed nerve growth in vivo.
Beresford,
Brachial muscles in the chick embryo: the fate of individual somites.
1983, Pubmed
Beresford,
Brachial muscles in the chick embryo: the fate of individual somites.
1983,
Pubmed
Blackshaw,
Onset of acetylcholine sensitivity and endplate activity in developing myotome muscles of Xenopus.
1976,
Pubmed
,
Xenbase
Carter,
Principles of cell motility: the direction of cell movement and cancer invasion.
1965,
Pubmed
Chamlet,
Selective growth of sympathetic nerve fibers to explants of normally densely innervated autonomic effector organs in tissue culture.
1973,
Pubmed
Cooke,
A clock and wavefront model for control of the number of repeated structures during animal morphogenesis.
1976,
Pubmed
,
Xenbase
Coughlin,
Target organ stimulation of parasympathetic nerve growth in the developing mouse submandibular gland.
1975,
Pubmed
Crick,
Diffusion in embryogenesis.
1970,
Pubmed
Davies,
Relation of target encounter and neuronal death to nerve growth factor responsiveness in the developing mouse trigeminal ganglion.
1984,
Pubmed
Dribin,
Conditioned medium enhances neuritic outgrowth from rat spinal cord explants.
1980,
Pubmed
Dribin,
Characterization of neuritic outgrowth-promoting activity of conditioned medium on spinal cord explants.
1982,
Pubmed
Ebendal,
Tissue explants affecting extension and orientation of axons in cultured chick embryo ganglia.
1977,
Pubmed
Erickson,
Embryonic fibroblast motility and orientation can be influenced by physiological electric fields.
1984,
Pubmed
Gundersen,
The effects of conditioned media on spinal neurites: substrate-associated changes in neurite direction and adherence.
1984,
Pubmed
Hamilton,
The formation of somites in Xenopus.
1969,
Pubmed
,
Xenbase
Henderson,
Neurite outgrowth from embryonic chicken spinal neurons is promoted by media conditioned by muscle cells.
1981,
Pubmed
Henderson,
Neurite-promoting activities for embryonic spinal neurons and their developmental changes in the chick.
1984,
Pubmed
Hinkle,
The direction of growth of differentiating neurones and myoblasts from frog embryos in an applied electric field.
1981,
Pubmed
,
Xenbase
Honig,
The development of sensory projection patterns in embryonic chick hind limb.
1982,
Pubmed
Jacobson,
Neurite outgrowth traced by means of horseradish peroxidase inherited from neuronal ancestral cells in frog embryos.
1985,
Pubmed
,
Xenbase
Keynes,
Segmentation in the vertebrate nervous system.
,
Pubmed
Kullberg,
Development of the myotomal neuromuscular junction in Xenopus laevis: an electrophysiological and fine-structural study.
1977,
Pubmed
,
Xenbase
Lance-Jones,
Motoneurone projection patterns in embryonic chick limbs following partial deletions of the spinal cord.
1980,
Pubmed
Lance-Jones,
Pathway selection by chick lumbosacral motoneurons during normal development.
1981,
Pubmed
Letourneau,
Cell-to-substratum adhesion and guidance of axonal elongation.
1975,
Pubmed
Letourneau,
Chemotactic response of nerve fiber elongation to nerve growth factor.
1978,
Pubmed
Lumsden,
Earliest sensory nerve fibres are guided to peripheral targets by attractants other than nerve growth factor.
,
Pubmed
MACKAY,
Observations on the terminal innervation of segmental muscle fibres in amphibia.
1960,
Pubmed
Moody,
Compartmental relationships between anuran primary spinal motoneurons and somitic muscle fibers that they first innervate.
1983,
Pubmed
,
Xenbase
Murphy,
Synthesis and secretion of a high molecular weight form of nerve growth factor by skeletal muscle cells in culture.
1977,
Pubmed
Nurcombe,
Evidence for neuron-survival and neurite-promoting factors from skeletal muscle: their effects on embryonic spinal cord.
1982,
Pubmed
Pollack,
Differentiating limb tissue affects neurite growth in spinal cord cultures.
1977,
Pubmed
Poo,
Lateral electrophoresis and diffusion of Concanavalin A receptors in the membrane of embryonic muscle cell.
1978,
Pubmed
,
Xenbase
Roberts,
A scanning electron microscope study of the development of a peripheral sensory neurite network.
1982,
Pubmed
,
Xenbase
Robinson,
Self-generated electrical currents through Xenopus neurulae.
1984,
Pubmed
,
Xenbase
SPERRY,
CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS.
1963,
Pubmed
Scott,
The development of the segmental pattern of skin sensory innervation in embryonic chick hind limb.
1982,
Pubmed
Sheard,
Critical periods in rat motoneuron development.
1984,
Pubmed
Smith,
Extracts of skeletal muscle increase neurite outgrowth and cholinergic activity of fetal rat spinal motor neurons.
1983,
Pubmed
Young,
Secretion of a nerve growth factor by primary chick fibroblast cultures.
1975,
Pubmed
