XB-ART-29617
Cell Differ
1984 Aug 01;143:179-87.
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In vitro inhibition of tubulin assembly by a ribonucleoprotein complex associated with the free ribosome fraction isolated from Xenopus laevis oocytes: effect at the level of microtubule-associated proteins.
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The 100 000 X g supernatant prepared from defolliculated Xenopus laevis oocytes inhibits, in a dose-dependent manner, the in vitro polymerization of rat brain neurotubulin. The oocyte inhibitory factor is thermolabile, totally inactivated by RNAse and partially by trypsin. A preliminary purification of the inhibitor showed that it is associated with the free oocyte ribosomes (80 S). The saturable binding of microtubule-associated proteins, essentially MAP2, to this 80 S ribonucleoprotein fraction is responsible for the inhibition of the in vitro tubulin assembly.
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Species referenced: Xenopus laevis
Genes referenced: map2 prss1