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J Neural Transm January 1, 1975; 36 (1): 71-81.
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The effect of porphyrin precursors on monosynaptic reflex activity in the isolated hemisected frog spinal cord.

Loots JM , Becker DM , Meyer BJ , Goldstuck N , Kramer S .

The porphyrin precursors beta-aminolevulinic acid (beta-ALA) and porphobilinogen (PBG) which accumulate, and are excreted in the urine in increased amounts during acute attacks of porphyria, were tested for their effects on reflex activity in the isolated hemisected spinal cords of Xenopus laevis. The two compounds were found to exert an inhibitory effect on monosynaptic ventral root responses, as well as on dorsal root responses (DRR) and dorsal root potentials (DRP). The latent period for inhibition of the monosynaptic response was longer than that for the DRR and DRP. The sensitivity of the preparations to the effect of the porphyrin precursors was subject to some seasonal variation. BETA-ALA and PBG did not effect conduction in isolated sciatic nerves at a concentration of 1 mg/ml.

PubMed ID: 1120952
Article link: J Neural Transm

Species referenced: Xenopus laevis
Genes referenced: utrn

References [+] :
Balcar, High affinity uptake of transmitters: studies on the uptake of L-aspartate, GABA, L-glutamate and glycine in cat spinal cord. 1973, Pubmed