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XB-ART-3313
Gen Comp Endocrinol 2004 Aug 01;1381:89-95. doi: 10.1016/j.ygcen.2004.05.006.
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Cloning and tissue distribution of the chicken type 2 corticotropin-releasing hormone receptor.

de Groef B , Grommen SV , Mertens I , Schoofs L , Kühn ER , Darras VM .


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We report the cloning of the complete coding sequence of the putative chicken type 2 corticotropin-releasing hormone receptor (CRH-R2) by rapid amplification of cDNA ends (RACE). The chicken CRH-R2 is a 412-amino acid 7-transmembrane G protein-coupled receptor, showing 87% identity to the Xenopus laevis and Oncorhynchus keta CRH-R2s, and 78-80% to mammalian CRH-R2s. The distribution of CRH-R2 mRNA was studied by RT-PCR analysis and compared to CRH-R1 distribution. Both CRH-R1 and CRH-R2 mRNA are expressed in the main chicken brain parts. In peripheral organs, CRH-R1 mRNA shows a more restricted distribution, whereas CRH-R2 mRNA is expressed in every tissue investigated, indicating that a number of actions of CRH and/or CRH-like peptides remain to be discovered in the chicken as well as in other vertebrates.

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Species referenced: Xenopus laevis
Genes referenced: crh crhr2 pomc