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XB-ART-34345
Nihon Rinsho October 1, 2006; 64 (10): 1942-9.

[Type C influenza].

Hongo S .


Abstract
The influenza C virus genome consists of seven single-stranded RNA segments of negative polarity. The hemagglutinin-esterase (HE) glycoprotein of influenza C virus has three biological activities, i.e. receptor-binding activity for N-acetyl-9-O-acetylneuraminic acid, fusion activity, and receptor-destroying activity, which is a neuraminate-O-acetylesterase. Unspliced mRNA from RNA segment 6 is first translated into a 374-amino-acid protein, P42. P42 is cleaved by signal peptidase, producing M1'' and CM2 proteins, composed of the N-terminal 259 amino acids and the C-terminal 115 amino acids, respectively. Xenopus laevis oocytes expressing influenza C virus CM2 protein demonstrated that CM2 protein forms a voltage-activated ion channel permeable to chloride ion.

PubMed ID: 17037372
Article link:


Species referenced: Xenopus
Genes referenced: cdk20 ces3.4