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Genes Dev December 1, 2006; 20 (23): 3232-7.
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Wnt/beta-catenin signaling regulates vertebrate limb regeneration.

Kawakami Y , Rodriguez Esteban C , Raya M , Kawakami H , Martí M , Dubova I , Izpisúa Belmonte JC .

The cellular and molecular bases allowing tissue regeneration are not well understood. By performing gain- and loss-of-function experiments of specific members of the Wnt pathway during appendage regeneration, we demonstrate that this pathway is not only necessary for regeneration to occur, but it is also able to promote regeneration in axolotl, Xenopus, and zebrafish. Furthermore, we show that changes in the spatiotemporal distribution of beta-catenin in the developing chick embryo elicit apical ectodermal ridge and limb regeneration in an organism previously thought not to regenerate. Our studies may provide valuable insights toward a better understanding of adult tissue regeneration.

PubMed ID: 17114576
PMC ID: PMC1686599
Article link: Genes Dev

Species referenced: Xenopus
Genes referenced: axin1 dkk1

Article Images: [+] show captions
References [+] :
Ahn, BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. 2001, Pubmed