Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-34996
Nucleic Acids Symp Ser (Oxf) 2004 Jan 01;48:285-6. doi: 10.1093/nass/48.1.285.
Show Gene links Show Anatomy links

Regulation of eukaryotic DNA replication by proliferation associated protein, PA2G4, in vitro.

Izuta S , Kitahara M , Hamaguchi T .


???displayArticle.abstract???
To search a novel factor possibly involved in the regulation of DNA replication for eukaryotic cells, we fractionated the Xenopus egg extract frequently used as a cell free DNA replication system, and obtained a single polypeptide of 50 KDa on SDS-polyacrylamide gel electrophoresis. Data of the amino acid sequence reduced from cloned gene of this protein revealed that this might be a Xenopus homolog of human PA2G4 that was known as a proliferation-associated protein or a cell cycle-regulated protein. Recombinant mouse PA2G4 protein also showed the inhibitory effect on the DNA replication reaction in Xenopus egg extract with the single-stranded DNA template. These results strongly suggest that PA2G4 may have an important role on the regulation of DNA replication in eukaryotic cells.

???displayArticle.pubmedLink??? 17150590
???displayArticle.link??? Nucleic Acids Symp Ser (Oxf)


Species referenced: Xenopus laevis
Genes referenced: pa2g4