XB-ART-35071Cell November 3, 2006; 127 (3): 453-5.
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The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.
PubMed ID: 17081965
Article link: Cell
Species referenced: Xenopus
Genes referenced: bard1 brca1 ran tbx2
Joukov, The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. 2006, Pubmed, Xenbase