XB-ART-35071
Cell
2006 Nov 03;1273:453-5. doi: 10.1016/j.cell.2006.10.020.
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A mitotic role for BRCA1/BARD1 in tumor suppression?
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The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.
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Species referenced: Xenopus
Genes referenced: bard1 brca1 ran tbx2
References :
Joukov,
The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly.
2006, Pubmed,
Xenbase