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Proc Natl Acad Sci U S A February 20, 2007; 104 (8): 2967-72.

Cannabinoid action in the olfactory epithelium.

Czesnik D , Schild D , Kuduz J , Manzini I .

The perception of odors is influenced by a variety of neuromodulators, and there is growing evidence that modulation already takes place in the olfactory epithelium. Here we report on cannabinergic actions in the olfactory epithelium of Xenopus laevis tadpoles. First we show that CB1 receptor-specific antagonists AM251, AM281, and LY320135 modulate odor-evoked calcium changes in olfactory receptor neurons. Second, we localize CB1-like immunoreactivity on dendrites of olfactory receptor neurons. Finally, we describe the cannabinergic influence on odor-induced spike-associated currents in individual olfactory receptor neurons. Here we demonstrate that the cannabinergic system has a profound impact on peripheral odor processing and discuss its possible function.

PubMed ID: 17301239
PMC ID: PMC1815290
Article link: Proc Natl Acad Sci U S A
Grant support: [+]

Species referenced: Xenopus
Genes referenced: avd cnr1
Antibodies: Cnr1 Ab1

Article Images: [+] show captions
References [+] :
Apelbaum, Orexin A effects on the olfactory bulb spontaneous activity and odor responsiveness in freely breathing rats. 2005, Pubmed