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Development April 1, 2007; 134 (7): 1431-41.
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Shroom family proteins regulate gamma-tubulin distribution and microtubule architecture during epithelial cell shape change.

Lee C , Scherr HM , Wallingford JB .

Cell shape changes require the coordination of actin and microtubule cytoskeletons. The molecular mechanisms by which such coordination is achieved remain obscure, particularly in the context of epithelial cells within developing vertebrate embryos. We have identified a novel role for the actin-binding protein Shroom3 as a regulator of the microtubule cytoskeleton during epithelial morphogenesis. We show that Shroom3 is sufficient and also necessary to induce a redistribution of the microtubule regulator gamma-tubulin. Moreover, this change in gamma-tubulin distribution underlies the assembly of aligned arrays of microtubules that drive apicobasal cell elongation. Finally, experiments with the related protein, Shroom1, demonstrate that gamma-tubulin regulation is a conserved feature of this protein family. Together, the data demonstrate that Shroom family proteins govern epithelial cell behaviors by coordinating the assembly of both microtubule and actin cytoskeletons.

PubMed ID: 17329357
Article link: Development
Grant support: [+]

Species referenced: Xenopus
Genes referenced: actl6a shroom1 shroom3 tubg1
Morpholinos: shroom3 MO1

Article Images: [+] show captions